Jornal da doença de Alzheimer e parkinsonismo

Abstrato

Application of APP/PS1 Transgenic Mouse Model for Alzheimer Disease

Hao Li, Yun Wei, Zhiyong Wang and Qi Wang

Alzheimer’s disease (AD), the most common neurodegenerative disorder, will not only reduce quality of life severely, but also bring heavy economic burden to the family and society. Slow progress in AD therapies partially due to lack of appropriate animal models. APP/PS1 transgenic mouse, a widely used animal model for AD, can be used in lots of aspects for AD related study, such as neuronal apoptosis, inflammation, cholinergic abnormal, neurogenesis disorder and synaptic plasticity. Despite all this, APP/PS1 transgenic mice model is not a perfect model, and more suitable animal model according to the aim of research should be established.