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Assessment of Interferential Currents Therapy Efficacy in Management of Primary Nocturnal Enuresis in 5-15 Years Old Children: A Randomized Clinical Trial

Parviz Yazdanpanah, Mousavizadeh Ali and Sadrollah Mehrabi

Introduction: Nocturnal enuresis affects about 15 percent of 5 years old children and because of its social (psychological) problems, it must be treated. Different treatment modalities such as imipramine, desmopressin, bed alarm have been used but applying of new and effective modalities can be an appropriate view. The aim of this study was to compare efficacy of interferential currents (IFC) with nasal spray of desmopressin in treatment of primary nocturnal enuresis of 5-15 years-old children.

Methods: This study was a randomized, clinical trial in which 39 patients with primary nocturnal enuresis received desmopressin (20 μg/day ) for 3weeks and if was responsive, leave off gradually in six months and 36 patients were selected randomly by simple randomization for IFC therapy (5 times /week, 20 minutes / session, up to 15 sessions). Efficacy of treatment was evaluated after accomplishment of therapeutic sessions and recurrence rate was evaluated one month later.

Results: In IFC group, complete response was observed in 25%, partial response in 36.1% and 38.9% had no response. In desmopressin group, response was observed in 87.2%, and 12.8% had no response (Risk ratio =2.4, 95% confidence interval (1.32-4.32)). The recurrence rate in IFC and desmopressin were 61% and 87.2%, respectively. Therapeutic side effects were not observed in any of patients (Risk Ratio=0.7, 95%CI (0.53-0.94)).

Conclusion: Desmopressin and IFC are effective and safe modalities for treatment of primary nocturnal enuresis of children. Although desmopressin has more efficacy but IFC has less recurrence rate