O Neurologista: Revista Clínica e Terapêutica

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Bilateral Internuclear Ophthalmoplegia, Deficiency and High Dose Administration of Vitamin D in Pediatric-Age Multiple Sclerosis: A Pediatric Case Report and Review of the Literature

Genç Sel C, Altıaylık Ozer P, Savaş Erdeve S, Aksoy E, Dedeoğlu O,and Oğuz KK

Oculomotor Disorders (OMDs) can be seen as the initial symptoms or during the course of multiple sclerosis (MS). Bilateral internuclear ophthalmoplegia (BINO) is a rare observation as clinical MS onset. BINO and its prognostic value in pediatric-age MS patients are not absolutely known. Vitamin D deficiency is thought to be associated with an increased disease activity in MS and vitamin D is supposed to be a potent immunomodulatory agent. Vitamin D deficiency, its probable effects on the disease pathogenesis, and high dose administration to a pediatric age patient presented with BINO are discussed in this report.