Arquivos de ciência

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By Modulating Microglia via the TLR4/Myd88/NLRP3/Casp1 Pathway, Endometrial Stem Cells Isolated by Menstrual Blood Suppress Neuroinflammation

Blaine Campbel

Many neurological illnesses frequently result in neuroinflammation as a reaction. A possible therapeutic for conditions linked to neuroinflammation is mesenchymal stem cell therapy. Mesenchymal stem cell effects are debatable, and the underlying process is not well known. In the current study, a mouse model of neuroinflammation created by peripheral lipopolysaccharide injection received an intravenous transplant of endometrial stem cells generated from menstrual blood. Endometrial stem cell-derived conditioned media was used to cultivate microglial cells that had been exposed to lipopolysaccharide.