Jornal de Bioquímica e Biologia Celular

Abstrato

Cell Signalling Pathways: An Overview of Molecular Communication Within Cells

Sonia D

Cell signalling pathways are essential components of cellular communication, enabling cells to respond to external stimuli and maintain homeostasis. This abstract provides a concise overview of cell signalling pathways, their significance, and their intricate molecular mechanisms. Cell signalling pathways encompass a vast network of molecular interactions that transmit information from the cell membrane to the nucleus and vice versa. They play a crucial role in regulating various cellular processes, including growth, differentiation, apoptosis, and immune responses. Dysregulation of these pathways is often associated with numerous diseases, such as cancer, diabetes, and autoimmune disorders. This abstract will outline the fundamental components of cell signalling, including receptors, ligands, and downstream effectors. It will discuss the classification of cell signalling into different types, such as autocrine, paracrine, endocrine, and juxtacrine signalling. The concept of signal transduction and the role of second messengers, such as cyclic AMP and calcium ions, will be elucidated. The abstract will also touch upon key signalling pathways, such as the MAPK/ERK, PI3K/AKT, and JAK/STAT pathways, highlighting their specific roles in cell behaviour and their therapeutic relevance. The crosstalk and integration of multiple signalling pathways will be emphasized to underscore the complexity of cellular regulation. Additionally, this abstract will explore emerging trends and technologies in the study of cell signalling, including the application of genomics, proteomics, and computational modeling to decipher intricate signalling networks. It will also underline the potential for targeted therapies based on a deeper understanding of signalling pathways.