Doenças Infecciosas Clínicas e Prática

Abstrato

Covid-19. A review in Covid-19 Infections and Treatment Through Understanding Viral First Main Steps in Respiratory Cells

Ashraf Marzouk El Tantawi

COVID-19 pandemic, induces a viral protein called open reading frame 3b(ORF3b) actively blocks the induction of type I interferon which are polypeptides that are secreted by infected cells antiviral defense called interferon, that produced by sick cells originally from ribosomal functions, which plays a really important role in slowing virus infection . Interferon is considered to be the initiative primary messages started from ribosome in the infected cells to follow the right original biological pathways to reach brain for asking for protection, recoveries and facing the viral infection. When Corona virus Started to infect human body started by respiratory system, that to minimize the intake oxygen to infected body , that when viral effects reach the blood stream in arteries & in capillaries wil affects on red blood cells to lysis & break their main - ve linkages which original presence in ATP molecules to restore their O2, phosphate gps, & their attached biological peptides that will bind & connected to viral protein to follow viral metabolism and viral toxic productions. Then the result will be reduction in gas exchanges in lungs that the intake oxygen will be minimized, and the restored CO2 in tissues & capillaries will be increased, that will leads to increase toxicities in capillaries then in arteries. When virus start to infect respiratory cells, first will lysis and destroy actin filaments and their isoform including their ATPase which considered to be a part of G-actin filaments. So, first Symptom is the Symptoms is the loss of sensations delivers by G-actin and tropomyosin isoforms, then loss of tast of smells which is done & transfered by G-actin and tRNAs directly to brain and then to neuron cells to give their responds & answers to those received messages of sensations and tastes. Using of ATP drug "Remdesivir" in the presence of CoA phospho_ transferase and thrombin inh or in the presence of retinol molecules will stop Corona virus effects & lysis their peptides, and recover infected cells with their full metabolic functions that releated to the reactivate G-actin and tropomyosin isoforms functions, also will Increase the molecular polarities effects on ribosomal production due to damaging of phosphorylation tools in cells by viral effects on cells and on actin micro filaments will lead to cleaning and removing accumulated micro molecules from capillaries and cleaning capillaries from micro +ve molecules , from arteries and from plasma, will lead to proper blood fluidity in capillaries and in arteries. The using of -Methyl-guanosine-5'-(α-fluoro)-monophosphate (®_MG5FmP) as antiviral molecules for treating the Covid-19 effects,in the presence of thrombin inh or retinol molecules will stop the full viral effects & will perform many metabolic functions at the same time as recover the damaged metabolic cycles, and damaging of cells contents & help for controlling many other metabolic cycles including signals and sensations & their transmission at the same time to brain and neuron, also is helpful for removing blood clotting while recovering respiratory cells & from the antiviral effects.