ISSN: 2155-9872

Jornal de Técnicas Analíticas e Bioanalíticas

Acesso livre

Nosso grupo organiza mais de 3.000 Séries de conferências Eventos todos os anos nos EUA, Europa e outros países. Ásia com o apoio de mais 1.000 Sociedades e publica mais de 700 Acesso aberto Periódicos que contém mais de 50.000 personalidades eminentes, cientistas de renome como membros do conselho editorial.

Periódicos de acesso aberto ganhando mais leitores e citações
700 periódicos e 15 milhões de leitores Cada periódico está obtendo mais de 25.000 leitores

Indexado em
  • Índice de Fonte CAS (CASSI)
  • Índice Copérnico
  • Google Scholar
  • Sherpa Romeu
  • Banco de dados de revistas acadêmicas
  • Abra o portão J
  • Genâmica JournalSeek
  • JornalTOCs
  • PesquisaBíblia
  • Infraestrutura Nacional de Conhecimento da China (CNKI)
  • Diretório de Periódicos de Ulrich
  • Biblioteca de Periódicos Eletrônicos
  • RefSeek
  • Diretório de indexação de periódicos de pesquisa (DRJI)
  • Universidade Hamdard
  • EBSCO AZ
  • OCLC – WorldCat
  • Acadêmico
  • Catálogo online SWB
  • Biblioteca Virtual de Biologia (vifabio)
  • Publons
  • Euro Pub
  • ICMJE
Compartilhe esta página

Abstrato

Development of HPTLC Method for Determination of Amlodipine Besylate and Olmesaratan Medoxomil Using Human Plasma by Liquid Liquid Extraction

Ambadas. R Rote and Sadhana.K. Kande

A simple, sensitive, rapid and economic high performance thin layer chromatographic method has been developed for determination of amlodipine besylate and olmesaratan medoxomil in human plasma by liquid liquid extraction using paracetamol as an internal standard. The plasma sample was extracted using mixture of methanol: acetonitrile (3.0: 0.1). A concentration range from 500-3000 ng/spot of amlodipine besylate and olmesaratan medoxomil was used for calibration curve respectively. The percent recovery of amlodipine besylate and olmesaratan medoxomil was found to be 90.41 and 90.64 % respectively. The mobile phase consists of chloroform: methanol (9:1, v/v). Densitometric analysis was carried out at wavelength 254 nm. The Rf values for amlodipine besylate, olmesaratan medoxomil and paracetamol was 0.50 ± 0.05, 0.26 ± 0.05 and 0.66 ± 0.05 respectively. The stability of amlodipine besylate and olmesaratan medoxomil in plasma was confirmed during three freeze-thaw cycles at ‘-20°C’, on bench during 24 h and post preparative during 48 h. The proposed method was validated statistically and by performing recovery study for determination of amlodipine besylate and olmesaratan medoxomil in human plasma by liquid liquid extraction.