Jornal de Farmacêutica Molecular e Pesquisa de Processos Orgânicos

Abstrato

Diabetes and Mitochondrial Fission and Fusion Dynamics

Tania Bagga*

Mitochondria are biosynthetic, bioenergetics and signaling organelle that regulates cellular and organism homeostasis in variety of ways. Mitochondrial dysfunction, a high generation of reactive oxygen species (ROS), and low level ATP are all symptoms of type 2 diabetes. Mitofusion-1, 2 and optic atrophy regulate mitochondrial fusion, whereas Mitochondrial fission 1, dynamic related protein 1 and mitochondrial fission regulate mitochondrial fission. PARKIN and PTEN-induced putative Kinase 1 are involved in the mitophagy process. In this review, we discuss about molecular pathways of mitochondrial dynamics in type 2 diabetes.