Nosso grupo organiza mais de 3.000 Séries de conferências Eventos todos os anos nos EUA, Europa e outros países. Ásia com o apoio de mais 1.000 Sociedades e publica mais de 700 Acesso aberto Periódicos que contém mais de 50.000 personalidades eminentes, cientistas de renome como membros do conselho editorial.

Periódicos de acesso aberto ganhando mais leitores e citações
700 periódicos e 15 milhões de leitores Cada periódico está obtendo mais de 25.000 leitores

Abstrato

Differences in Acetic Acid Ototoxicity in Guinea Pigs are Dependent on Maturity

Takafumi Yamano, Hitomi Higuchi, Tetsuko Ueno, Takashi Nakagawa, Tetsuo Morizono

Objectives: The objective was to study if the difference exist in drug ototoxicity between less mature and mature guinea pigs.

Methods: The matured animal group had a body weight of 400 g and the less mature animal group had a body weight of 200 g. After compound action potential of the eight cranial nerves was measured, the middle ear cavity was filled with acetic acid.

Results: The less mature animal group was more sensitive to the acetic acid treatment than the more mature animal group.

Conclusion: We suggest that a difference in ototoxicity of certain otic drop treatments may exist between pediatric and adult patients.