Otorrinolaringologia: Acesso Aberto

Abstrato

Differences in Acetic Acid Ototoxicity in Guinea Pigs are Dependent on Maturity

Takafumi Yamano, Hitomi Higuchi, Tetsuko Ueno, Takashi Nakagawa, Tetsuo Morizono

Objectives: The objective was to study if the difference exist in drug ototoxicity between less mature and mature guinea pigs.

Methods: The matured animal group had a body weight of 400 g and the less mature animal group had a body weight of 200 g. After compound action potential of the eight cranial nerves was measured, the middle ear cavity was filled with acetic acid.

Results: The less mature animal group was more sensitive to the acetic acid treatment than the more mature animal group.

Conclusion: We suggest that a difference in ototoxicity of certain otic drop treatments may exist between pediatric and adult patients.