Sistema Gastrointestinal e Digestivo

Abstrato

Differences in Expression of Fatty Acid Synthase among Histological Subtypes of Intraductal Papillary Mucinous Neoplasm of the Pancreas – An Experience of Immune Histochemical Analysis

Hiroshi Maekawa, Hajime Orita, Tomoaki Ito, Mutsumi Sakurada, Tomoyuki Kushida, Koichi Sato and Ryo Wada

Background: Fatty acid synthase plays an important role in tumorigenesis. We investigated the expression of fattyacid synthase in cases of intraductal papillary mucinous neoplasm of the pancreas, thought to be one of the precancerous lesions of pancreatic cancer, using immunohistochemistry. We also examined whether there are any differences between histological subtypes in intraductal papillary mucinous neoplasm of the pancreas. Methods: Eight cases of intraductal papillary mucinous neoplasm were examined using immunohistochemistry. Fatty acid synthase and Ki-67 expressions were investigated, and positive cellular rates were compared with histological subtypes of intra-ductal papillary mucinous neoplasm. Results: Pathologically, cases of the gastrictype were represented as low-grade dysplasia; however, cases of the intestinal or pancreatobiliary type were classified as intermediate- or high-grade dysplasia. Concerning fatty acid synthase expression, positive cellular rates of the gastric type were lower than those in cases of the intestinal or pancreatobiliary type. The positive cellular rates of Ki-67 expression were similar to those of fatty acid synthase expression. Conclusion: Although this study included only a small sample number, fatty acid synthase expression differed between the gastric and other subtypes in intraductal papillary mucinous neoplasm of the pancreas.