Sistema Gastrointestinal e Digestivo

Abstrato

Drug Rediscovery: Preventing Off-label Prescription and Reducing Health Care Costs: The Case of Thioguanine in the Netherlands

Chris J. J. Mulder, Dirk P. van Asseldonk, Nanne K de Boer

We have concerned ourselves at the gastroenterology unit of the VU University Medical Center with drug repositioning since 2001. Generic therapy, often successfully used off-label in daily practice and well described in literature in large observational studies, should be further developed for safe and economically viable use. To prevent off-label use legislative authoritiesshouldstimulate re-registration of these drugs.