Arquivos de ciência

Abstrato

Exploring the Modulation of Pharmacodynamics and Liver Carboxyl Esterase 1A Metabolism in the Herb-Drug Interaction of Clopidogrel and Xuesaitong Dispersible Tablet

Shi-Tang Ma

Clopidogrel and Xuesaitong dispersible tablet (XST) have been clinically proven to be effective for treating cardio cerebrovascular disease. The present study was to investigate the herb-drug interaction of Clopidogrel and XST by modulation of the pharmacodynamics and liver Carboxyl esterase 1A metabolism. Xuesaitong dispersible tablet product has been clinically proven to be effective for treating cardio-cerebrovascular disease. Furthermore, herb-drug interactions between the XST product and drugs that are commonly co-administered, such as aspirin, must be explored to ensure safe clinical use