Bioquímica e Fisiologia: Acesso Aberto

Abstrato

Fast Side-Chain Dynamics: Measurement, Analysis, and Their Role in Protein Function

Chad M Petit

Proteins are dynamic molecules that use coordinated atomic fluctuations to achieve proper function. These motions have fundamental implications for not only understanding how proteins function, but current methods of structure based drug design. In this review, we focus on providing an overview of the NMR experiments to detect side-chain motions and their applications, to characterize to conformational entropy, allostery, and proper protein function.