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Guillain-Barre Syndrome associated SARS-CoV-2: What Poses Less Risk, Vaccinate or Infected with COVID?

María Dolores Calabria Gallego

Introduction: Among the neurological diseases possibly associated with COVID-19 (coronavirus disease 2019) infection, Guillain-Barre syndrome has been postulated since the start of the pandemic, even more so when vaccination has also come into play.

Objectives: A bibliographic review is carried out to assess the true risks of suffering Guillain-Barre syndrome secondary to vaccination against SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infection and of developing it secondary to SARS-CoV-2 infection.

Materials and methods: A search for articles was carried out in the PubMed-MEDLINE database between June 2021 and July 2021.

Results: The scarcity of studies that can provide solid evidence stands out, with most of the publications being clinical case reports or case series. Two epidemiological studies with contradictory results stand out.

Conclusion: With the information currently available, it is not possible to conclude that there is an association between SARS-CoV-2 infection or secondary to vaccination with Guillain-Barre syndrome. Therefore, the recommendation to avoid vaccination for fear of a recurrence of Guillain-Barre syndrome does not seem to be normative at the present time.