Toxicologia: Acesso Aberto

Abstrato

Heavy Metal-Induced Neurotoxicity and Calcium Channel Involvement

Paolo Manetti

Heavy metal-induced neurotoxicity is a burgeoning concern in modern society due to widespread environmental contamination. This article delves into the intricate relationship between heavy metal exposure and neurological damage, focusing on the pivotal role of calcium channels in this intricate interplay. Heavy metals like lead, mercury, and cadmium have been recognized as potent neurotoxins, capable of disrupting calcium channel function. This disruption leads to a cascade of detrimental effects within neurons, including impaired synaptic transmission, excito toxicity, synaptic plasticity deficits, and neuroinflammation. Understanding the mechanisms underlying heavy metal-induced neurotoxicity and its connection to calcium channels is crucial for developing effective strategies to mitigate the adverse effects on the nervous system and prevent related neurological disorders.