Jornal Internacional de Inflamação, Câncer e Terapia Integrativa

Abstrato

Human Leukocyte Antigen G as a Novel Target for Switch-based Chimeric Antigen Receptor Natural Killer Cell Therapy of Solid Cancer

peter D Canoll

Challenges present with chimeric antigen receptors (CARs) adoptive cell therapy against solid tumors have been lacking a ubiquitous tumor-associated antigen across different tumor types, tumor antigen expression heterogeneity, and the immunosuppressive nonphysical tumor microenvironment.  Thus, we developed a switch anti human leukocyte antigen (HLA)-G CAR that binds to HLA-G1~G7