Jornal de Transplante Clínico e Experimental

Abstrato

Huntington's disease Stem Cell Transplantation?s Potential Therapeutic Application and Pathogenesis

Diana Jacobs

Repetitive CAG or glutamine expression along the Huntington gene’s coding region results in the progressive neurodegenerative disorder known as Huntington’s disease (HD). Certain abnormalities in movement, emotional disturbances, dementia, and cognitive impairments are the effects of this disease. To this date, there could be no legitimate remedy for this uncommon and deadly neurological condition yet there have been sure headways in the field of hereditary creature model examination studies to explain the comprehension of the pathogenesis of this condition. Currently, HD follows a specific therapeutic approach that only treats symptoms and does not address the disease’s underlying cause. Stem cell therapy has the potential to be a game-changer in the search for a cure. The pathogenesis, efficacy, and clinical viability of the therapeutic application of stem cell transplantation in Huntington’s disease have all been discussed in this review. A brief list and analysis of the applications of this revolutionary therapy on genetically modified animal models has been provided.