Jornal Mundial de Farmacologia e Toxicologia

Abstrato

Induced Pluripotent Stem Cell-derived Cardiomyocytes can serve as Acellular Models for Cardiac Toxicity Testing

Moyes Yuan

Induced pluripotent stem cell (iPSC) science is developing thrilling new possibilities for cardiovascular lookup by way of offering structures to learn about the mechanisms of ailment pathogenesis that ought to lead to new treatments or divulge drug sensitivities. In this review, the practicable usefulness of iPSC-derived cardiomyocytes in drug improvement as nicely as in drug toxicity checking out is discussed, with a center of attention on the achievements that have been already made in this regard. Moreover, the critical steps that have to be taken earlier than this science can be widely used in drug discovery and toxicology assessments are highlighted.