Imunologia: Pesquisa Atual

Abstrato

Inflammasomes in Cancer Caused by Inflammation

Peter James

An essential multiprotein complex known as the inflammasome is involved in inflammatory immunological responses. The autoactivation of caspase-1 and subsequent cleavage of proIL-1β and proIL-18, which are important sources of inflammatory symptoms, will occur as a result of inflammasome activation. On the other hand, inflammasomes also have anticancer properties through the regulation of the immune system and a specific type of programmed cell death known as pyroptosis. The final immunological effects are significantly influenced by the phases and compartments in which inflammasomes are activated. We provide a comprehensive overview of the roles played by inflammasomes in malignancies brought on by inflammation, particularly gastrointestinal and skin cancers. Additionally, information is provided about the inflammasome-related items' existing therapeutic uses and potential future research avenues [1].