Pesquisa do Journal of Mucosal Immunology

Abstrato

Insights into Mucosal Immune Cell Trafficking: Mechanisms, Implications, and Therapeutic Opportunities

Noorjahan P

Mucosal immune cell trafficking plays a crucial role in maintaining homeostasis and defending against pathogens at various mucosal surfaces, including the respiratory, gastrointestinal, and genitourinary tracts. This review aims to provide insights into the mechanisms underlying mucosal immune cell trafficking, its implications in health and disease, and the therapeutic opportunities it presents. Mucosal immune cell trafficking is a highly regulated process involving intricate interactions between immune cells, endothelial cells, epithelial cells, and chemokines. The trafficking of immune cells to mucosal tissues is governed by a combination of chemotactic gradients, adhesion molecules, and signaling pathways. These mechanisms ensure proper recruitment, retention, and surveillance of immune cells within the mucosal microenvironment. Understanding the implications of mucosal immune cell trafficking is critical for unraveling the pathogenesis of various mucosal diseases, including inflammatory bowel disease, asthma, chronic obstructive pulmonary disease, and sexually transmitted infections. Dysregulation of immune cell trafficking can lead to chronic inflammation, tissue damage, and impaired immune responses. Elucidating the specific mechanisms involved in these diseases can provide valuable targets for therapeutic intervention. Exploiting the knowledge of mucosal immune cell trafficking has opened up new therapeutic opportunities. Strategies aimed at modulating immune cell migration, such as blocking adhesion molecules or inhibiting chemokine receptors, have shown promise in preclinical and clinical studies. Furthermore, targeted delivery of immune cells to specific mucosal sites using engineered nanoparticles or cell-based therapies holds great potential for immunotherapy and vaccine development. In conclusion, understanding the mechanisms, implications, and therapeutic opportunities associated with mucosal immune cell trafficking is crucial for advancing our knowledge of mucosal immunology and developing novel therapeutic approaches. By targeting the processes governing immune cell migration, it may be possible to modulate immune responses, ameliorate chronic inflammatory conditions, and enhance mucosal immune protection. Continued research in this field is essential for improving human health and addressing the challenges posed by mucosal diseases.