Jornal de Farmacêutica Molecular e Pesquisa de Processos Orgânicos

Abstrato

Introducing the Effect of Chinese Chlorella as a Photosensitizing Drug at Different Temperatures

M-Ali H Al-Akhras, Aljarrah K, Ghaseb N Makhadmeh and Al Shorman

Chinese Chlorella is natural algae seafood is widely used as a food substitute. Treatment of localized cancer cells by natural photosensitizer drugs extracted from herbs received intensive improvements with very high demands. Fractional hemolysis of the red blood cells incorporated with Chinese Chlorella in vitro has been reported. Continuous and delayed photohemolysis at different concentrations and different irradiation times were investigated. The samples irradiated with high-pressure arc lamp of intensities 58.07 J/cm² ± 1.45 and 64.21 J/cm² ± 1.98. The power dependent parameters of the relationship between time required to rupture 50% of the cells (t50) with different concentration and different irradiation time are found to be 0.63 ± 0.06 and 3.38 ± 0.17 respectively. These results suggested that, Chinese Chlorella could be one of the natural potential drugs in photodynamic therapy.