Sistema Gastrointestinal e Digestivo

Abstrato

Involvement of Mitochondrial Reactive Oxygen Species in Gastric Carcinogenesis

Masato Tamura, Michihiro Mutoh, Gen Fujii, and Hirofumi Matsui

Gastric cancer is one of the most common malignancies in many countries. Environmental gastric cancer risk is known to be associated with Helicobacter pylori infection, a high intake of salty foods, and alcohol consumption. Here, we provide evidence of linkage of mitochondrial reactive oxygen species (ROS) to several environmental gastric cancer risks. Moreover, ROS correlate with gastric cancer invasion and metastasis, the most important factor to decide a patient’s prognosis. We also show correlation between mitochondrial ROS and gastric cancer invasion by using a normal gastric mucosal cell line (RGM-1), a cancerous mutant RGM-1 subclonal (RGK-1) and a MnSOD-expressing RGK-1 cell-line, used for a scavenging mitochondrial ROS. This mini-review summarizes role of ROS in gastric carcinogenesis and aims to provide a clue in developing useful treatments against gastric cancer.