Sistema Gastrointestinal e Digestivo

Abstrato

Jatropha tanjorensis Ameliorate Effects of Aspirin Induced Stomach UIcer in Wistar Rats

Umoren Elizabeth Bassey, Okon Idara Asuquo, Brown Providence Idabie, Owu Daniel Udofia, Bassey Augustine Lawrence, Okon Effiom Eitm

Background: Jatropha tanjorens is considered a potential source of medicinal agents to treat different diseases. Aim: This study investigated the comparative effects of J. tanjorensis ethanolic leaves extract and amlodipine on gastro intestinal function in aspirin induced ulcer in wistar rats.

Methods: Wistar rats of both sexes (180 g-200 g) were divided into 6 groups (n=5). Group 1 received rat chow; group 2 received (5 mg/kg) of amlodipine orally. Group 3 received (200 mg/kg) of J. tanjorensis orally group 4 received aspirin only (250 mg/kg). Group 5 received (250 mg/kg) of Aspirin+Amlodipine (5 mg/kg). Group 6 received aspirin (250 mg/kg)+J. tanjorensis (200 mg/kg). After 14 days of treatment, animals were sacrificed and blood samples were collected for biochemical analysis while the stomach was harvested for histological analysis.

Results: Stomach acid secretion, gastric pepsin secretion and ulcer score all increased significantly (p<0.001) in the aspirin treated group as compared to other treatment group and control respectively. Aspirin significantly reduced adherent mucus secretion when compared to other treatment groups and control respectively at (p<0.05). When compared to control, ulcer score in Aspirin+Amlodipine and Aspirin+J. tanjorensis treated groups both showed significant increase (p<0.05). Aspirin treated animals showed decreased goblet cell with marked inflammation that was reversed by J. tanjorensis treatment. The results suggest that J. tanjorensis ameliorates aspirin induced stomach damage and that amlodipine treatment does not compromise the integrity of the stomach.

Conclusion: It is concluded that the leaves extract of J. tanjorensis ameliorated the effect of aspirin induced ulcer in Wistar rats; and that amlodipine does not adversely affect gastric secretion and predispose to gastric ulcer.