Jornal de Obesidade e Terapia para Perda de Peso

Abstrato

Lipoprotein Lipase Activation Improve the Cachexia and Obesity

Masataka Kusunoki, Kazuhiko Tsutsumi, Chen Tana, Daisuke Sato and Takao Nakamura

Cachexia is defined as an extreme wasting condition with marked weight loss. It is observed in paints with cancer and severe infectious disease. Obesity is one of the fasted growing major diseases in developed and developing countries. As has been persuasively argued, long-term imbalance between intake and expenditure of fat is a central factor in the etiology of obesity. We hypothesized that elevating lipoprotein lipase (LPL) activity would cause an improvement of cahexia and obesity. To test this hypothesis, we studied the effects of the LPL activator NO-1886 in cachexia and obese animals.