Jornal de Pneumologia e Doenças Respiratórias

Abstrato

Macrophages and Systemic and Tumor Th1 and Th2 Inflammatory Profile in Lung Cancer: Impact of Underlying Chronic Respiratory Disease

Esther Barreiro

Introduction: Habitual respiratory conditions, especially habitual obstructive pulmonary complaint (COPD), and seditious events uphold lung cancer (LC). We hypothecated that biographies of T coadjutor 1 and T coadjutor 2 cytokines and type 1 and type 2 macrophages (M1 and M2) are differentially expressed in lung excrescences and blood of cases with NSCLC with and without COPD and that the rate M1/ M2 specifically may impact their survival.

Methods: In blood, seditious cytokines( determined by enzyme- linked immunosorbent assay) were quantified in 80 cases with LC( 60 with LC and COPD( the LC- COPD group) and 20 with LC only( the LC-only group)) and lung samples (excrescence and nontumor) from those witnessing thoracotomy( 20 in the LC- COPD group and 20 in the LC-only group).

Results: In the LC- COPD group compared with in the LC-only group, systemic situations of excrescence necrosis factor- α, interleukin- 2( IL- 2), transubstantiating growth factor- β, and IL- 10 were increased, whereas vascular endothelial growth factor and IL- 4 situations were dropped. In lung excrescences, situations of excrescence necrosis factor- α, transubstantiating growth factor- β, and IL- 10 were advanced than in nontumor parenchyma in the LC- COPD group, whereas IL- 2 and vascular endothelial growth factor situations were advanced in excrescences of both the LC-only and LC- COPD groups. Compared with in nontumor lung, M1 macrophage counts were reduced whereas M2 counts were increased in excrescences of patient groups, and the M1/ M2 rate was advanced in the LC- COPD group than the LC-only group. M1 and M2 counts didn't impact cases’ survival.

Conclusions: The relative ascendance of T coadjutor 1 cytokines and M1 macrophages in the blood and excrescences of cases with underpinning COPD indicate that a stronger proinflammatory pattern exists in these cases. Inflammation shouldn't be targeted totally in all cases with LC. Screening for the presence of underpinning respiratory conditions and identification of the specific seditious pattern should be carried out in cases with LC, at least in early stages of their complaint.