Câncer de mama: pesquisa atual

Abstrato

Metformin in the Fibrocystic Breast Disease

Helga Marques

Foundation and Purpose Fibrocystic illness (FCD) of the bosom as an exceptionally normal medical issue in ladies has estrogen dependent and proliferative highlights. No effective administration methodology has been approved for this issue, up until this point. The hostile to hyperglycaemic specialist metformin has both enemy of proliferative and estrogen-stifling effects. Consequently, we examined metformin as an administration methodology for FCD. The review was a twofold visually impaired fake treatment controlled randomized clinical preliminary. Premenopausal ladies with FCD as per history, actual test and ultrasound, who had quantifiable microcyst groups on ultrasound (US) were placed the review. Oral fake treatment and metformin tablets (500 mg) were involved two times day to day by members in the mediation and control gatherings. Size and number of microcyst groups on US and the emotional aggravation score were recorded when the intercession. 154 members were arbitrarily apportioned into two gatherings of 77 intercessions and 77 controls. The diminishing in size of the biggest microcyst bunch in every patient and the mean decline in number of microcyst groups were not genuinely significant. Be that as it may, those microcyst groups which were≥14 mm became significantly more modest after metformin use. Furthermore, in the subset of members with torment at gauge, a bigger extent in the mediation bunch experienced something like half decrease in torment score in the mediation versus 44.2% (19/43) in the fake treatment gatherings, P=0.031). Our review showed that metformin may be effective in the administration of FCD. Further examinations are proposed for confirmation of this subject.