Jornal de doenças infecciosas e terapia

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N,N,N-Trimethyl Chitosan and Its Potential Bactericidal Activity: Current Aspects and Technological Applications

Débora P Facchi, Suelen P Facchi, Alessandro F Martins

N,N,N-Trimethyl chitosan (TMC) is one of most important chitosan derivative with stronger bactericidal property. Currently, the TMC has been attracted considerable attention, because it contains quaternized ammonium moieties (-+N(CH3)3) in its network. Its cationic property leads to a renowned bactericidal power. Besides, TMC has appropriate biocompatibility, biodegradability, mucoadhesive capacity and greater solubility at pH close to physiological condition regarding chitosan. In this way, there are not sources regarding revision papers toward TMC bactericidal action. So, this revision work reports the TMC potential to be applied in many fields, depicting its bactericidal performance, as well as, its bactericidal mechanism and some current technological aspects that must be considered.