Jornal de Bioquímica e Biologia Celular

Abstrato

Organelle Structure and Function: A Comprehensive Overview

Sumona D

Organelles are specialized substructures within eukaryotic cells that play pivotal roles in cellular organization, metabolism, and function. This review provides a comprehensive overview of the structure and function of key organelles, emphasizing their intricate interplay in maintaining cellular homeostasis. The nucleus, acting as the cellular control center, houses genetic material and orchestrates vital cellular processes. Mitochondria, often referred to as the powerhouses of the cell, are responsible for energy production through oxidative phosphorylation. The endoplasmic reticulum, a complex membrane system, is crucial for protein synthesis, folding, and transport. Meanwhile, the Golgi apparatus processes and modifies proteins for secretion or cellular use. Lysosomes, the cell's recycling centers, degrade cellular waste, and maintain cellular cleanliness. The cytoskeleton provides structural support, facilitates cell movement, and aids in intracellular transport. Peroxisomes participate in lipid metabolism and detoxification processes. The endomembrane system, comprising the endoplasmic reticulum, Golgi apparatus, and vesicles, regulates the synthesis and transport of lipids and proteins. This review explores recent advancements in understanding organelle dynamics, interactions, and their implications for cellular health. The emerging field of organelle communication and its impact on cellular responses to stress and environmental cues are also discussed. Additionally, the role of organelles in diseases, such as neurodegenerative disorders and metabolic syndromes, is highlighted. A comprehensive understanding of organelle structure and function is essential for unraveling the complexities of cellular physiology and pathology. Insights gained from this exploration contribute to the development of targeted therapeutic strategies for diseases associated with organelle dysfunction, fostering advancements in cell biology and medicine.