Jornal de Biologia de Citocinas

Abstrato

Pathogenesis and Suppression of Thyroid Autoimmune Disease are Mediated in Part by Cytokines

Siobhan MO Connor

The part of cytokines in the pathogenesis of Autoimmune Thyroid Complaint (ATD) has been considerably delved over the once times. In cases with ATD, these motes can be set up in both the thyroid and spots of extrathyroidal complications of the complaint. Cytokines can affect the autoimmune process through a number of mechanisms including reclamation of seditious cells and up-regulation of motes essential for perpetuation of the seditious response in the affected point. In addition, cytokines can intrude with thyroid hormone conflation, entwining them directly in thyroid dysfunction set up in ATD cases. Also, these motes can modulate the function of cells in orbital towel, which results in localised oedema, indicating a central part for cytokines in the development of proptosis, the cardinal point of thyroid associated ophthalmopathy.