Jornal de Patologia Clínica e Experimental

Abstrato

Post-Transplant Lymphoproliferative Disorders after Allogeneic Hematopoietic Stem Cell Transplantation: Case Report and Literature Review

Dingbao Chen, Qian Jiang, Danhua Shen

PTLDs are disorders with a spectrum ranging from “early” polyclonal proliferations resembling nonspecific plasma cell hyperplasia or infectious mononucleosis to clonal proliferations of B or T/NK cells. The incidence of PTLD after HSCT is approximately 0.8%-4.0%. The clinical manifestations of PTLD are variable related to the morphological types, sites, and patient’s general condition. Four basic histological types of PTLD have been identified: Nondestructive PTLD, polymorphic PTLD, monomorphic PTLD and classical Hodgkin Lymphoma. Treatments for PTLD comprise reduction of immunosuppression, rituximab, chemotherapy, and adoptive immunotherapy.