Patologia Diagnóstica: Acesso Aberto

Abstrato

Significance of Expression of Cancer Stem Cell Markers CD133

AlSaiyed Alshenay

Pancreatic adenocarcinoma of ductal origin (PDAC) is considered one of the most aggressive malignancies and also one of the most chief causes of deaths related to cancer. It has a very poor prognosis and high recurrence rate. We investigated the expression of CSC markers (CD133 and nestin) in different grades of pancreatic intraepithelial neoplasms (PanINs) and PDAC and correlate the expression levels of these markers with clinicopathological data with the aid of Ki67 expression. Our findings showed that both cancer stem markers (CSC) are related to the PanINto- PDAC sequence. Both markers may contribute in proliferation index, tumor differentiation and infiltration. So they may also be useful for developing new therapeutic modalities for PDAC.