Doenças Neuroinfecciosas

Abstrato

The Blood-Brain Barrier and Bioenergetics in Stroke

Emily Hone, Sajad Sarvari, Faezeh Moakedi, Yuxin Liu, Xuefang Ren

Stroke is an overwhelming neurological disease with very limited treatment options. As blood-brain barrier (BBB) integrity is well-implicated in the prevention of brain injury, its regulation may prove beneficial for stroke patients. BBB cerebro-vascular endothelial cells primarily utilize mitochondria as their energy-producing source, and mitochondrial function has revealed importance in outcomes for tissue post-stroke. In this review, bioenergetics in relation to BBB permeability in stroke is discussed. Moreover, what causes mitochondrial dysfunction following stroke is explored.