Pesquisa do Journal of Mucosal Immunology

Abstrato

The Oral Mucosa's Lichenoid Tissue Reactions

Svetelina Velikova

Lichenoid alterations in the oral mucosa can occur in a variety of lesions and have a variety of etiologies. Clinical and histologic similarities can occur in immune-mediated illnesses such as lichen planus, mucous membrane pemphigoid, discoid lupus erythematosus, and graft-versus-host disease. Lichenoid reactions to dental materials like amalgam, as well as several systemic medicines, are extensively documented. Oral dysplasia can also have a lichenoid histology, which might disguise the potentially malignant component. Proliferative verrucous leukoplakia is a unique clinical condition that clinically mimics oral lichen planus and necessitates careful correlation of clinical and pathologic features. The purpose of this study was to identify the tissue-derived extracellular vesicles immunogen implicated in the pathogenesis of oral lichen planus (OLP) and its variants oral lichen planus (OLP).

Lichen Planus is an autoimmune disease of the skin and mucous membranes, including the oral mucosa and sexual organs, with the potential to progress to cancer. Xerostomia and salivary gland hypofunction are common signs and complications of oral lichen planus (OLP), the origin of which is unknown. Aquaporins (AQP) are a type of membrane channel cell protein that is involved in intercellular water permeability. This study examines the expression of the aquaporin-3 (AQP3) gene in oral tissues of OLP patients and a control group for the first time. In this study, 30 OLP patients and 30 healthy people were chosen. The AQP3 gene expression was evaluated using the Real-Time PCR technique.