Jornal de Diabetes Clínica

Abstrato

The Pancreatic INS-1E Beta Cells Activation of the TRPV4 Channel Increases the Release of Insulin in Response to Glucose Through Calcium- Dependent Processes

Harrty Burger

Insulin secretion by pancreatic beta cells is a vital process for glucose regulation in the human body. The activation of the Transient Receptor Potential Vanilloid 4 (TRPV4) channel in these cells has recently been recognized as a significant contributor to insulin release. This study investigates the impact of TRPV4 channel activation on insulin secretion in response to glucose, with a particular focus on the involvement of calcium-dependent processes. Glucose-stimulated insulin secretion involves a cascade of events in pancreatic beta cells. Elevated blood glucose levels lead to glucose entry into beta cells and subsequent ATP production. ATP-sensitive potassium channels close as a result of increased ATP levels, leading to membrane depolarization. This depolarization triggers the opening of voltage-gated calcium channels, resulting in calcium influx into the cells.