Toxicologia: Acesso Aberto

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The Role of Manganese Superoxide Dismutase in Skin Cancer Prevention

FermAn Priyadarsi

Manganese Superoxide Dismutase is an enzyme involved in the cellular defense against oxidative stress. In the context of skin cancer prevention, MnSOD plays a crucial role in protecting skin cells from oxidative damage induced by reactive oxygen species. Excessive ROS production, triggered by UV radiation and other environmental factors, can lead to DNA damage and the development of skin cancer. MnSOD acts as an antioxidant enzyme, converting superoxide radicals into less harmful hydrogen peroxide, thereby reducing oxidative stress and preserving cellular integrity. Reduced levels of MnSOD have been observed in skin cancer tissues, suggesting its importance in preventing skin cancer. Genetic variations in the MnSOD gene have also been associated with an increased risk of skin cancer. Strategies that support MnSOD activity, such as antioxidant-rich diets and topical application of antioxidants, can enhance its protective effects. However, skin cancer prevention requires a comprehensive approach, considering various genetic, environmental, and lifestyle factors.