Jornal Internacional de Inflamação, Câncer e Terapia Integrativa

Abstrato

The role of Wnt signaling and treatment mechanism in leukemia

Seyyed Hossein Hassanpour, Mohammad Amin Dehghani, Seyyedeh Zeinab Karami, Fatemeh Dehghani

Increased activity of Wnt pathway has been observed in a huge number of malignancies. This pathway can function as a prosurvival factor in leukemia stem cells and early committed leukemic precursors and its inhibition is regarded as a therapeutic approach. Accordingly, the aim of this review is to evaluate the Wnt inhibitors used in leukemia models.