Jornal de pesquisa e tratamento oncológico

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Tissue-Specific Differences in Mesenchymal Stromal Cells Influence Homing and Function

Christen L. Ebens, Julia A. Riedl, Jakub Tolar

Mesenchymal Stromal Cell(MSC) therapies to modulate inflammation and promote tissue regeneration in Recessive Dystrophic Epidermolysis Bullosa(RDEB) are under active investigation in clinical trials. However, optimal tissue source and fundamental mechanisms of clinical benefit of MSCs require additional investigation. Riedl et al.recently published “ABCB5+ dermal mesenchymal stromal cells with favorable skin homing and localimmunomodulation for Recessive Dystrophic Epidermolysis Bullosa treatment,” in Stem Cells [1] highlightingdifferences in homing of MSCs, impact on local macrophages, and distinct transcriptional profiles related to tissue oforigin (skin dermis versus bone marrow). Elucidation of these critical features and underlying mechanisms will aid intranslation of MSC cellular therapies to promote wound healing in RDEB.