Jornal de Neuroimunologia Clínica e Experimental

Abstrato

Unraveling the Role of Tumor Necrosis Factor in Neuroinflammation Linked to Parkinson's Disease and Therapies

Samara Urban De Oliva

Neurodegenerative diseases Parkinson's complaint is a progressive neurodegenerative complaint associated with neuroinflammatory responses that lead to the neurodegeneration of the dopaminergic neurons. These neuroinflammatory mechanisms involve colorful cytokines produced by the actuated glial cells. Tumor Necrosis factor α(TNF α) is one of the major intercessors of the neuroinflammation associated with neurodegeneration. TNF α has a binary part of neuroprotection and neurotoxicity in the brain. The effective pathways of TNF involve colorful signaling pathways transduced by the receptors TNFR1 and TNFR2. Effective remedial strategies have been produced targeting the neurotoxic gets of the Tumor Necrosis Factor and the associated neurodegeneration which includes the use of Dominant Negative Tumor Necrosis Factor