Pesquisa do Journal of Mucosal Immunology

Abstrato

Young Patients with Gastric Cancer

Heriberto Medina

Although it may be found earlier, gastric cancer is often an aging-related disease and is most frequently discovered after the sixth decade of life. Most nations and areas do not have screening programmes for the 5.0% of gastric cancer (GC) patients who are diagnosed before the age of 40. With the exception of the United States, the incidence of gastric cancer in young adults (GCYA) has decreased over time in most other nations. A young adult’s susceptibility to GC may be influenced by lifestyle choices, environmental factors, and genetic changes. The majority of GCYA patients have cancers that are classified as either gnomically stable or microsatellite stable/epithelial-Mesenchymal transition subtypes, with mutations in CDH1 being the most prevalent genetic abnormalities. The characteristics of GCYA include a higher frequency in females, more aggressive tumour behaviours, detection at late stages, less comorbidities and better treatment candidates, as well as survival outcomes that are comparable to or better than those of older patients. The two most efficient approaches to reduce GC mortality are lowering the prevalence of GC and identifying at a relatively early stage, taking into account the larger loss of life-years in younger individuals. To accomplish these objectives, there needs to be a change in the low level of knowledge of GCYA among the general public, policymakers, doctors, and researchers.