Revista de Pesquisa Científica da Nutrição

Abstrato

Assessing the Therapeutic Potential of Cinnamon zeylanicum (Cinnamon) and Syzygium cumini (Jamun) Seeds on Hyperglycemia in Diabetic Rats

Rafique A*, Inam-ur-Raheem M, Asghar A and Shafqat Rasool M

Many traditional plants have been used to combat fatal diseases such as diabetes mellitus. These plants have been shown to possess antioxidant activities, improving the diabetes complications. Chemical, minerals and phytochemical analyses of cinnamon and jamun seeds were done and bio-evaluation trials were conducted on diabetic rats by feeding cinnamon and jamun seeds extracts for a period of 60 days. The impact of cinnamon and jamun seeds administration was observed. Blood glucose, insulin level, lipid profile, liver and kidney functions were assessed. Diabetic rats revealed an increase in the levels of blood glucose, total cholesterol and triglycerides. In contrast, the levels of insulin and high density lipoprotein cholesterol (HDL-cholesterol) were reduced. It is found that the oral administration of cinnamon and jamun seeds showed a reduction in glucose level, total cholesterol and triglycerides whereas an increase in insulin level and HDL-cholesterol were noted. Also cinnamon and jamun seeds restored the altered liver and kidney function (aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), and serum urea and serum creatinine) levels to near normal.