Revista de Medicina Respiratória

Abstrato

Larger Air Spaces Instead of Small ones Resulting Reduced Surface Area of the Lungs

Himender M

Histone deacetylases include four classes of enzymes that catalyze the removal of acetyl functional groups from the lysine residues of both histone and non-histone proteins. Histone deacetylases is one of the class I Histone deacetylases and has been encoded by its gene in humans. Since Histone deacetylases has been overexpressed in a variety of human cancers, it has been employed as one of the attractive therapeutic anticancer targets based on structural features of this protein and inhibitory activity and selectivity of targeting drugs.