Jornal de Farmacocinética e Terapêutica Experimental

Abstrato

The solubility measurements of crystallized Ibuprofen at low

Afrina Afrose,

The objective of this study was to determine the effect of five pharmaceutically used excipients e.g. L-lactose, hydroxy propyl methyl cellulose (HPMC)1 , leucine, D-mannitol and Pluronic F127 (Pl F127) on the ibuprofen (Ibu) solubility in water (W) - ethanol (E) co-solvent systems. The solubility was measured in water (W) - ethanol (E) mixtures from 0 to 50% w/w ethanol at 10, 25 and 40 °C by the dissolution method using UV spectrophotometry. The Ibu solubility without excipients in water (zero ethanol) was low (~ 50 ppm); however, increased near exponentially with increasing ethanol content.